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Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, et al

This is because hair follicle regeneration is a dynamic process critically reliant on energy metabolism and cellular metabolic reprogramming, wherein the fate of HFSCs is determined by the coordinated regulation of glucose, lipid, and amino acid metabolism (Plikus et al., 2008

Acknowledgements We are grateful for the support from the Laboratory Animal Center at National Taiwan University, College of Medicine and Flow Cytometric Analyzing and Sorting Core of the First Core Laboratory, National Taiwan University College of Medicine for providing the service

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GSH functions as a signaling molecule which activates the breast cancer stem cell phenotype through copper chelation that leads to an inhibition of mitogen-activated protein kinase kinase (MEK) activity, leading to inactivation of MEK1-ERK signaling, FoxO3 dephosphorylation, and nuclear translocation ultimately leading to enrichment of breast cancer stem cells [158] High ROS production in cancer cells requires high activity of cellular antioxidant systems making cancer cells hypersensitive to exogenous agents that damage their antioxidant capability