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Third, lack of HO-1 expression in bone marrow-derived cells resulted in atherosclerotic plaques with a larger inflammatory component, suggestive of greater vulnerability for rupture (Orozco et al., 2007)

To address this, future interventions should prioritize integrated synbiotic therapies, combining carefully selected probiotics with specific prebiotics to enhance microbial engraftment, stabilize gut ecology, and reinforce host metabolic and immune homeostasis (Balthazar et al., 2022)

Sleep, circadian rhythm, and mood Sleep disruption and mood disorders exist in a bidirectional relationship so tight that untangling cause from effect is often impossible