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thus, the complete picture of how full-length HGF recruits and dimerizes c-MET has not been depicted, hindering our understanding of the exact activation mechanism of c-MET

Cytokines Cell Mol Therap 2000, 6: 177187

Similarly, peptides with the C-terminal sequence Lys-Asp-Glu-Leu motifs of KDEL (binding to KDEL receptors on ER membranes) or AAKKKA (peptide interactions with specific ER membrane proteins) are also capable of ER targeting (197199)

We also observed activation of other stress responses in individual tissues, such as the integrated stress response (ISR) (Atf4, Atf5) in liver and muscle, oxidative stress (Nrf2, Hmox1) in muscle, and mitochondrial biogenesis (Pgc1a) and the mitokine Gdf15 in eWAT (Fig 1G)

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