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48 From a structural and functional standpoint, endurance training such as swimming and long-distance running induces a volume overload which leads to eccentric cardiac hypertrophy, as characterized by a proportional change in ventricle wall thickness and chamber enlargement

Sun, Q., Want, B., Li, Y., et al

Metal-Responsive Regulation of Enzyme Catalysis Using Genetically Encoded Chemical Switches
Importantly, a recent cost-effectiveness analysis using a Markov decision model showed that total thyroidectomy may be both more effective and less costly over the long term than continued medical therapy in euthyroid HT patients with disabling symptoms (58)

Depletion of B cells and the beneficial effect of rituximab typically lasts for 4 to 9 months in MG but may persist for a longer time
this can be caused by poor lifestyle choices, stress, or aging