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Acetaminophen (APAP) is a traditional antipyretic and analgesic drug [194], which can combine with erastin to promote cell ferroptosis by regulating Nrf2 nuclear translocation and inhibits the growth of lung cancer xenograft tumors [195]
It showed activity in all tested cancer cells harboring oncogenic KRAS with an IC50 of 20 ng/mL
Diseases with an autoimmune component damage particular cells mitochondria
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Int J Biol Macromol 118:12841292
