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Description
NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict
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Potentially reducing the need for daily supplementation

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Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse

Like methionine, it can contribute to mild GI discomfort at higher doses in some individuals
