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Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA

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However, one school of thought maintains that inclusion of placebo subjects in FIH trials, which are underpowered, is not justified or useful.33 Most AEs observed in FIH studies are just reported as probably related with minimal interpretation of causality and more serious AEs are typically followed with greater diligence and concern

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