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In the first step, enzymes such as cytochrome P450 monooxygenases catalyze various reactions (oxidation, reduction or hydrolysis) to expose or introduce a functional moiety on hydrophobic substrates

PGRN and AREG PGRN and AREG have emerged as critical players in GBM pathogenesis, each contributing uniquely to tumorigenesis, progression, and therapeutic resistance

TRAF3, tumour necrosis factor receptor-associated factor 3

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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Tsujita T, Peirce V, Baird L, Matsuyama Y, Takaku M, Walsh SV, et al