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Metabolic unpredictability: Simultaneously altering multiple metabolic pathways incretin signalling, glucagon activity, and NAD+ metabolism without clinical oversight introduces unpredictable physiological consequences

DNA Repair (Amst) 2006;5:145-52

14: 1586-1595 (2018) Bode AM, Dong Z

For example, enzyme levels are low before birth but rise markedly within hours after delivery, coinciding with the activation of gluconeogenesis in the newborn

No lethal dose has been established in animal studies, and the peptide appears to have wide safety margins

[DOI] [PubMed] [Google Scholar] Stevens J.L., Anders M.W
