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In the first study, the authors reported the appearance of dying OLs expressing activated caspase 3 which was accompanied by a significant decrease in NogoA-positive mature OLs after 6 days of CPZ feeding at the dose of 0.3%, and they also claimed that apoptotic OLs were present not only in the corpus callosum but also in the cortex 2 days after the start of the CPZ diet, although they did not show the data (Hesse et al., 2010).The second and more recent study showed the loss of CC1-positive OLs in the corpus callosum as early as 2 days after CPZ exposure in the standardized CPZ model (Jhelum et al., 2020)

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Although there are now reports suggesting that peptides can act on timescales of around a second, this is still slower than the millisecond response speeds of neurotransmitters

This can be caused by any reason like allergies, infection or any medicine