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SunYLiSLiuHBaiHHuKZhangRet alOxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome

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10.1038/nature10954 [DOI] [PMC free article] [PubMed] [Google Scholar] Mann A., Illing S., Miess E., Schulz S

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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These results come from lab and animal settings, not skincare clinical trials, but they help explain why copper peptides are often described as repair-focused rather than just cosmetic
