o-palmitoyl-l-carnitine Cardiolipin Stabilizes and Increases Catalytic Efficiency of Carnitine Palmitoyltransferase II and Its Variants S113L, P50H, and Y479F performance liquid chromatography coupled to tandem mass spectrometry (HPLC Palmitoylcarnitine - an overview |

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As E2 and E3 mice are known to have increased longevity relative to E4 mice ( Although ApoE4 has been shown to disrupt Blood Brain Barrier (BBB) integrity and reduce its glucose uptake ( APOE genotype effect on the cerebrovascular uptake of L-carnitine, its metabolites, or FAs at 26 weeks of age

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2 Mitochondrial dysfunction in ASD From a clinical point of view, mitochondrial dysfunction in ASD may be the cause of seizures, motor delay, fatigue and neurodevelopmental regression ( Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP ( A central mechanism often implicated is the dysfunction of Electron Transport Chain (ETC), which plays a crucial role in ATP production

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