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Another danger is the possibility of bacterial contamination during the manufacturing process

They sound very important.

Seattle, WA: University of Washington (1993)

Compounding allows prescribers to adjust the hydroquinone concentration beyond the 4% ceiling of most commercial products and to customize the vehicle for patient tolerance

doi: 10.1097/FBP.0000000000000689

References: Wu, M., Cronin, K., & Crane, J