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Within the conserved intracellular cavity for G protein coupling, three pairs of residues are non-conserved, including S149/A162 ICL2 , N304/K324 6.26 , and N374/H394 8.47 (S149, N304, and N374 in CCK1R
doi: 10.1016/j.biopha.2020.110234, 51
