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Similarly, when the lower eye fold tendon gets loose over time, due to aging (or other causes), the eyelid can turn in (entropion) or out (ectropion)

For example, Pim2 kinase directly activates glycolysis by phosphorylating glycolytic enzymes PGK1, PDHA1, and PFKFB2, driving M1 polarization in inflammatory arthritis (135)

Phosphodiesterase superfamily The PDEs superfamily contains 11 different gene families: PDE1, PDE2, PDE3, PDE4, PDE5, PDE6, PDE7, PDE8, PDE9, PDE10 and PDE11

S.SinisaloJ.et al (2012)

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A principal component analysis (PCA) was able to differentiate the proteome of the four groups
