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Description
Rational conversion of chromophore selectivity of cyanobacteriochromes to accept mammalian intrinsic biliverdin
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Furthermore, more than propranolol, NaBPC157 was able to markedly attenuate the otherwise advanced lesions in the stomach of the alcohol treated rats

2008 Bear, Stearns & Co., Inc

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The key is to treat optimization like an experiment measure, adjust, and let your physiology guide the protocol changes (if any)