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While preliminary studies and observational signals suggest potential thyroidal effects, no RCTs have evaluated progression of Hashimoto thyroiditis or Graves disease under GLP-1RA therapy [32,58]

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Key trials like STEP, SURPASS, and SELECT have demonstrated their efficacy in glycemic control (HbA1c reductions of 1.02.0%) [1, 3, 4], weight loss (1020% mean body weight reduction) [2, 3, 4], and cardiovascular risk reduction [4, 7]

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Activation of PPAR improves insulin sensitivity in the adipose tissue, liver and skeletal muscle 10,11,23