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In the 70s, Yukna et al

Lastly, missing values were imputed by sampling N values from a normal distribution (seed = 12345) and using them as replacements only when there are no valid values in a group of replicates of a condition or if there is only one valid value which is below the first tertile of intensities in the data set
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[DOI] [PMC free article] [PubMed] [Google Scholar] 186.Azzouz, D., Khan, M

Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis
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