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Table 4 Berberine in clinical trials for metabolic and inflammatory disorders

Incidence has been reported in more than 110 countries, and approximately 1.6 billion individuals are considered at risk, underscoring their status as a recognized international public health concern [13]

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Under conditions of oxidative stress, excess H 2 O 2 and O 2 can increase the phosphorylation levels of RIPK1 and RIPK3, activating MLKL and inducing membrane rupture [237]

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in addition, andrographolide can significantly reduce the immune response in mice and alleviate MS symptoms in mice with autoimmune encephalomyelitis by suppressing T-cell activation and antibody responses against myelin sheaths ( 5.5 Systemic lupus erythematosus Systemic lupus erythematosus is a multisystem damage disease