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PTP1B is a negative regulator of the leptin and insulin signaling pathways, so it has emerged as an attractive novel target for the treatment of both type 2 diabetes and obesity [51]

Published research documents their roles in extracellular matrix regulation, fibroblast activity, and growth factor expression

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10.1186/s12943-018-0864-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 89.Erlebacher A
