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Discussion The major findings of our study are that advanced age is associated with impaired NVC responses in humans and that age-related decreases of circulating IGF-1 levels predict the magnitude of age-related decline in functional hyperemia

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Common symptoms of B12 deficiency include: Persistent fatigue that doesn't improve with rest Brain fog and difficulty concentrating Numbness or tingling in hands and feet Pale or yellowish skin tone Mood changes like depression or irritability Balance problems or dizziness If these symptoms sound familiar, don't ignore them

Side effects are uncommon but may include mild injection-site reactions, flushing, or headache

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