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This inhibition then translates into an observed reduction in the astrocytic release of IL-6 and monocyte chemoattractant protein-1 (MCP-1) in primary human cell cultures, thereby reducing inflammatory signaling and peripheral immune cell recruitment, respectively (Rizzo et al., 2019

Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients

The antibody for phosphor (p)-Nrf2 was obtained from Abcam, Inc

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132 , e153173 (2022)

They exert their effects by activating the transmembrane receptor tyrosine kinase rearranged during transfection (RET), which regulates cell survival, differentiation, proliferation, migration, chemotaxis, branching, neurite outgrowth and synaptic plasticity (93) ( Figures 1D, E )