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This can result in a reduced need for thyroid hormone replacement, particularly in patients who initially required higher doses due to obesity-related factors like increased inflammation or altered hormone metabolism

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Bowden J., Davey Smith G., Burgess S

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5 A number of reasons have been suggested for this lack of efficacy in certain individuals, ranging from genetic mutations causing poor responses to pharmacokinetic differences and concomitant medical conditions

284 , R1427R1435 (2003)

Case Report: Semaglutide-associated depression: A report of two cases