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Phase 3 trials include a 4mg maintenance arm specifically because some individuals achieve excellent results at lower doses

Carfilzomib is formulated with SBE--CD as an inclusion complex in Kyprolis , a powder for solution for infusion, in order to improve aqueous solubility [112]

doi: 10.3390/ijms13078308

One example escalation schedule observed in Phase 2 obesity trials proceeded broadly as follows: Weeks 14: 2 mg once weekly (initiation phase) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Weeks 13 onwards: Up to 12 mg once weekly (the maximum dose explored in Phase 2 trials) This is an illustrative example only

All the other chemicals and reagents were of analytical reagent grade, purchased from commercial sources

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