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This process is exacerbated by the downregulation of protective enzymes like GPX4 and the disruption of the system Xc-/GSH/GPX4 axis
doi: 10.1016/j.jff.2014.09.006

The total thiol and GSH levels in livers are markedly reduced in untreated STZ-induced diabetic rats
The peptides modulate the thymus-pineal axis, representing an integrated network affecting immune function through coordinated peptide signaling
McDougald R

Metabolism 54 , 2432 (2005)
