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Under physiological and T2D conditions, PTEN also has a negative regulatory function in insulin signaling through its inhibition in the PI3K pathway (232, 233)

These RNA molecules, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), were found to be involved in various aspects of neuropathic pain, such as neuronal plasticity, inflammation, and immune responses [203]

[DOI] [PubMed] [Google Scholar] 134.McKenna MC, Scafidi S, Robertson CL

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KG is derived from multiple metabolic pathways, including oxidative decarboxylation of isocitrate via isocitrate dehydrogenases (IDHs) and glutaminolysis ( Fig