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BBB dysfunction in these pathologies may result in compromised transport and permeability properties of the barrier as well as in alterations in cerebrovascular regulatory mechanisms of blood flow, with ensuing perturbed signalling between brain endothelium and associated cells, such as glia and neurons

Proc Natl Acad Sci U S A 1996

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Multiple studies have shown that the Notch and transforming growth factor-1 (TGF-1)/Smad3 pathways could trigger epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) accumulation, leading to renal interstitial fibrosis (85)

PMID: 35792488 J Transl Med Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth

An improvement in symptoms (urgency and frequency of urination) occurred as early as 2 weeks after the procedure