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As multi-ligand receptors, RAGE, AGE-related scavenger receptors, and AGE-R not only bind to AGE but also interact with other ligands to initiate multiple intracellular signaling pathways, subsequently triggering a range of pathophysiological processes [16, 29]

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Elsevier Saunders, 2012, pp 55-64

Eradication of virus prior to transplantation has been associated with a low likelihood of posttransplantation infection, providing a strong incentive to treat HCV infection prior to transplantation, as long as the risks of pre-transplantation treatment are acceptable154