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There is currently no evidence pointing definitively one way or another when it comes to the effect of GLP-1RAs on muscle mass in patients with cancer, and both alternatives are reasonable viewpoints until studies provide clearer evidence

Possible side effects of GLP-1 drugs include: Nausea Vomiting Diarrhea Constipation Loss of body weight, including muscle Increases in fertility Changes in appetite and food preferences Changes in mood

GLP-1 regulates skeletal muscle blood flow by recruiting skeletal and cardiac muscle microvasculature ( 1.4 Anti-inflammatory effects of GLP-1 GLP-1 exhibits its anti-inflammatory actions through direct and indirect mechanisms

This uniformity makes the tirzepatide escalation more predictable than semaglutide, where the jumps are uneven (0.25, then 0.5, then 0.7, then 0.7 again)

If cardiovascular outcomes of tirzepatide are similar to GLP-1 RAs, the medication may be used by practitioners preferentially prior to using GLP-1 RAs in patients with or without diabetes who desire weight-loss

Frequently asked questions Does GLP-1 cause green poop