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5963 The flexibility of the -helical hairpin can be attributed to the hinge region that connects it to the lipoyl domain

The ferroptosis inducer erastin irreversibly inhibits system x- and synergizes with cisplatin to increase cisplatins cytotoxicity in cancer cells

GSH is preferentially transported in the reduced form as GSSG is virtually impermeable and is entrapped and accumulated in the microsomal lumen creating the oxidizing environment necessary for the formation of disulfide bonds and for the proper folding of proteins [76]

Documented results from research protocols suggest modest but meaningful improvements

Baliga, M

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