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Hence, in order to grow beyond a certain size, emerging tumor mass must develop angiogenic ability for limitless supply of nutrients

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Moreover, APOE promotes tumor growth and proliferation in PTC through glycolysis, and analysis has shown that the FTO/APOE axis inhibits PTC glycolysis by modulating the IL-6/JAK2/STAT3 signaling pathway [86]

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Abnormal redox status induced during tamoxifen treatment cues cell survival signaling activation, implying that modulation of cell survival or apoptosis may be an ancillary molecular target in addition to tamoxifen therapy and warrants further investigation

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