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NAD+ does more than produce energy - it acts as a co-substrate for enzymes such as sirtuins and PARPs that maintain DNA repair and genomic stability

Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

doi: 10.1038/s41598-024-81845-6 60

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SFN also caused demethylation of CpGs islands of Nrf2 gene promoter, which acts as regulator in the cellular oxidative stress decreasing the carcinogen-induced tumorigenesis, in TRAMP C1 cells