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Oncol Lett 14:19932000

Making two water molecules requires four electrons, so Complex IV must accept, handle, and pass to molecular oxygen four separate electrons, causing the oxidation state of oxygen to be sequentially changed with addition of each electron

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Lipoic acid, either as a dietary supplement or a therapeutic agent, modulates distinct redox circuits because of its ability to equilibrate between different subcellular compartments as well as extracellularly