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Mitochondrial complex I as a pathologic and therapeutic target for Parkinsons disease

doi: 10.1158/1535-7163.MCT-20-0430

The structures of some isocereulides differed from that of cereulide by substitution of L- O -Val by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D- O -Leu by D- O -Val (isocereulide B), thus indicating a relaxed substrate specificity of the A domains and an inefficient proof reading by CesT 18

Proliferation and cancer biology IGF-1R signaling is mitogenic and anti-apoptotic it promotes cell division and cell survival

Signature effects of vector-guided systemic nano bioconjugate delivery across blood-brain barrier of normal, Alzheimers, and tumor mouse models