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Fauth EB, Jackson MA, Walberg DK, et al

Overall, the stomach empties in proportion to a meals caloric load rather than its macronutrient composition (7577)

10.1021/bm049284w 72 RaoZ.LinZ.SongP.QuanD.BaiY

It turns out that restricting calories in some animals also preserves the rhythm of melatonin production

Response to treatment and monitoring : Most patients notice improvement in fatigue within days to weeks of starting treatment, though neurological symptoms may take several months to resolve and may not fully reverse if long-standing
