lysosomal glutathione Ferroptosis regulation in lysosome iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation and glycine sourced in Japan MITF or TFEB overexpression restores

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Mechanistically, intranasally administered agents may be absorbed through the olfactory epithelium or trigeminal nerve endings and transported to the brain via extracellular diffusion and intracellular axonal pathways, which may partially bypass BBB-related constraints (Raghav et al., 2023

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