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This modification is reversible by cytoplasmic GRX1, but not mitochondrial GRX2, highlighting compartment-specific redox regulation (58)

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In normal cells, hydrogen peroxide is promptly degraded by either glutathione peroxidase (GSHPX) or catalase, but in red cells of G6PD-deficient subjects, GSHPX activity is impaired because GSH is in short supply (Fig 4), and catalase may also be impaired because the intracellular NADPH concentration is low (Gaetani et al , 1994, 1996)

Am J Physiol Regul Integr Comp Physiol 286:R431R444 [DOI] [PubMed] [Google Scholar] Taslimi P, Gulin (2017) Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes

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The results include improved mental clarity, sustained energy, and improved cellular repair