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All three assays use human embryonic renal cells were stably transfected with either cDNA of the human IGF-IR gene (HEK IGF-IR) or with cDNA of the human IR-A or human IR-B gene (HEK IR-A or IR-B)

Pathologically, HFD apparently leads to defective cardiac FAO and subsequent lipotoxicity, thereby evoking a set of pathological reactions including oxidative stress, DNA damage, inflammation, and insulin resistance

Reconstitution of PEG MGF requires the use of sterile water for injection or an appropriate buffer (e.g

doi: 10.1016/S0140-6736(87)91771-5 38 BlakeDRLunecJAhernMRingEFBradfieldJGutteridgeJM

these findings are modeldependent and primarily preclinical (see Key references)

They are not designed to diagnose, treat, cure or prevent any disease