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Activation of PDHK1 inhibits pyruvate dehydrogenase (PDH), thereby inhibiting the production of acetyl-CoA from pyruvate and redirecting it toward lactic acid production instead

The pulmonary system must provide a precise barrier between the external environment and the fluid-filled tissues to facilitate gas exchange

The observed accumulation of oxidized (and/or otherwise modified) proteins in older lenses is consistent with the diminished capacity of these protective systems to keep pace with the insults that damage lens proteins

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However, due to their reversibility, these side effects do not pose any lasting danger
