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Later, Chi et al
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Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats
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However, accumulating evidence suggests that all LDH isoforms retain the inherent capacity to mediate pyruvate-to-lactate conversion accompanied by NAD+ regeneration, and that LDHA and LDHB can functionally compensate for each other under metabolic stress (44,45)
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