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Mechanistically, leptin up-regulates CBS expression through FOXO3a, promotes pre-TRH production by inhibiting the mTOR pathway, and then increases TH production and decreases corticosterone production, thus reducing fat deposition and improving insulin resistance induced by FHD (74)

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In the case of multiple tests, false discovery rate control using the Benjamini and Hochberg procedure 108 implemented in the p.adjust function of R was used

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