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Maybe, possibly, we actually have no idea

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doi: 10.1016/j.celrep.2021.109526 [DOI] [PubMed] [Google Scholar] 42.Cusi K

There is no established pharmacological mechanism by which semaglutide would directly cause hot flushes or vasomotor symptoms, although it should be noted that GLP-1 receptor agonists can increase heart rate and rarely cause hypersensitivity reactions which may include flushing