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These approaches support patient stratification into molecular endotypes, prediction of therapy response or toxicity using interpretable models such as elastic-net regression, gradient boosting, and survival forests, and the identification of actionable microbial or metabolic pathways through explainability techniques like SHAP values (Wang C

Shi Z, Chen J, Wumaner A, Li M, Liang C, Li M

doi: 10.1177/2150132720984426

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10.1161/CIRCULATIONAHA.109.915215 69 MohananA.GuptaR.DubeyA.JagtapV.MandhareA.GuptaR

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