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Structurally identical to the biologically active 129 N-terminal amino acids of native GHRH, Sermorelin preserves full receptor agonist activity

Future research directions should focus on clarifying the molecular interactions between lipid metabolism and microglial polarization, identifying reliable lipid biomarkers for disease progression and developing optimized lipid-targeted therapeutic interventions

Researchers observed that ipamorelin binds and activates GHSR on somatotrophs, triggering Gq-coupled phospholipase C signaling, IP3-mediated calcium release, and GH exocytosis

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[DOI] [PubMed] [Google Scholar] [57].Knecht KT, Bradford BU, Mason RP, Thurman RG