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We also constructed an M25AD ADC using monomethyl auristatin E (MMAE) and obtained potent inhibition of mesothelioma xenografts in vivo at a dose of 3 mg/kg (Figure 4)

Reported side effects of corticosteroids include: Hydroelectrolytic disorders: sodium retention, potassium loss, hypokalemic alkalosis, fluid retention, congestive heart failure in susceptible patients, hypertension Musculoskeletal: muscle weakness, myopathy, loss of muscle mass, aggravation of myasthenic symptoms in myasthenia gravis, osteoporosis, vertebral compression fractures, aseptic necrosis of the head of the femur and humerus, pathologic fracture of long bones, tendon rupture Dermatological: impaired wound healing, atrophy and thinning of the skin, fragile skin, petechiae and ecchymoses, facial erythema, increased sweating, suppression of reactions to skin tests, allergic dermatitis, urticaria, and angioedema

Intense exercise creates a temporary spike in oxidative stress

however, excessive production or insufficient clearance leads to oxidative and nitrosative stress, which can damage lipids, proteins, and nucleic acids

Here's a concrete example: Month one on tirzepatide, start with Tier 1 only

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