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Here, the authors report a phase I clinical trial investigating the combination of radiotherapy, TPE, and ICI rechallenge in patients with ICI-refractory metastatic melanoma with high PD-L1

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In skin lesion tissues of HS patients, IRAK4 protein levels were significantly higher than in non-lesion areas and positively correlated with disease severity

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This demonstrates the importance of astrocyte metabolism in neuronal functionality and depression