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In addition, HO-1 overexpression in the cardiac allograft results in prolongation of the graft survival, which is much more dramatically improved when HO-1 is overexpressed in the recipient host rather than the donor organ (Araujo et al., mice, with HO-1 mRNA levels ~60% of wild-type (WT) controls displayed shorter survival, despite a much larger degree of HO-1 upregulation after the transplant (unpublished), suggesting that basal HO-1 could be key in antiinflammatory protection

Kazuhiro, H., Junichi, I., Shogo, F., Masahiro, N

Because CIN cells are already under stress, a small metabolic disturbance that does not impact normal cells might result in significant levels of oxidative stress and consequent cell death [9]

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It has been the subject of numerous clinical trials investigating its ability to eradicate H
We summarized the basic information and possible mechanisms of some representative secondary metabolites for H
