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Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis

Loss of Ozz or Alix in mouse skeletal muscle reciprocally influences each others roles as mitochondrial QC systems: Ozz deficiency increases the pool of exosome-loaded Slc25A4, while Alix deficiency redirects Slc25A4 to proteasomal degradation

356,357 Targeting pathways that improve Schwann cell metabolism and support axonal energy requirements may offer new therapeutic avenues (Fig

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5 Non-cardiovascular toxicity Interestingly, various non-cardiovascular effects have been described following CCA overdose, such as confusion, agitation, impaired consciousness and seizures, 5,8,11-13 which might be caused by hypoperfusion of the central nervous system