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Proc Natl Acad Sci USA 103:14121417 Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP (2007) Genome-wide profiling of DNA reveals a class of normally methylated CpG island promoters

Thus, while the lactate-TCA cycle-oxidative phosphorylation (OXPHOS) axis is well supported, whether lactate enters mitochondria directly or is first converted to pyruvate in the cytosol remains uncertain, and the preferred route may vary across different tissue types or metabolic conditions [2]

doi: 10.1016/j.bcp.2023.115464 12 DuDLiuCQinMZhangXXiTYuanSet al