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6.2.3.2 Myelin vacuolization and demyelination NO-induced Vit B12 inactivation results in MMA accumulation ( 6.2.3.3 Cytokine dysregulation and myelin swelling Elevated levels of proinflammatory cytokines, such as TNF-, and reduced levels of epidermal growth factor have been observed in Vit B12-deficient states ( 6.3 Clinical manifestations of nervous system injury NO-induced injuries are classified into acute, subacute, and chronic phases

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2.7 western blotting Total proteins were extracted from liver tissues using RIPA buffer (Beyotime Biotech, China) supplemented with 1 mM PMSF (Beyotime Biotech, China)

Xun L, Topp E, Orser CS (1992) Glutathione is the reducing agent for the reductive dehalogenation of tetrachloro-p-hydroquinone by extracts from a Flavobacterium sp